MERS-CoV human betacoronavirus molecular evolutionary analyses
An analysis of the sequence of the first UK case including deep sequencing of within-patient diversity can be found here:
Cotten M, Lam TT, Watson SJ, Palser AL, Petrova V, Grant P, Pybus OG, Rambaut A, Guan Y, Pillay D, Kellam P, Nastouli E (2013) Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerg Infect Dis. Volume 19, May 2013 http://dx.doi.org/10.3201/eid1905.130057
A phylogenetic and temporal analysis of the first 5 genomes (plus the phylogenetic position of some fragments from the Essen/Qatar patient) can be found in Figure 3 of this paper:Drosten C, et al. (2013) Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. The Lancet Infectious Diseases. 17 June 2013 http://dx.doi.org/10.1016/S1473-3099(13)70154-3A more extensive phylogenetic and phylodynamic analysis of an additional 21 complete or partial genome sequences from across Saudi Arabia:Cotten et al (2013) Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study. The Lancet. 382: 1993 - 2002.
http://dx.doi.org/10.1016/S0140-6736(13)61887-5This paper is Open Access but Elsevier have put it behind an email address gathering register-wall. Download a PDF under the Creative Commons licence (CC BY-NC-ND, Copyright © 2013 Cotten et al.) from here.